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PE-22-28 Peptide

PE-22-28 research peptide vial, spadin derivative, Pro Peptide Canada
Brain + Mood
A spadin-based peptide acting on the TREK-1 channel, a target antidepressant research keeps circling back to.
Vial size 5mg Use Peptide Planner

Out of stock

SKU: PP-PE2228-5MG
Tags ≥99% purity brain peptide brain research channel research COA verified ion-channel research lyophilized mood-signaling research neural research neural-signaling research neuropeptide neuroscience research PE-22-28 peptide canada potassium channel research peptide spadin derivative spadin peptide synthetic peptide TREK-1

Made in Canada

Domestic facility, no border delays

We guide you

Peptide Planner with every order

Cold-pack shipping

Free on every order

Same-day dispatch

Order by 2pm PT

Crush-proof box

Arrives intact, every time

Swab included

Sterile-wipe before each draw

What PE-22-28 is

Research peptide, plain

A short peptide derived from a natural molecule called spadin, studied for brain-signaling channels.

Newer, with an early research file.

Brain cells have tiny channels that control their signaling. PE-22-28 is studied for how it relates to one specific channel.

What it is: a lab-made peptide. (A peptide is a tiny chain of the building blocks your body uses.) It's derived from a natural molecule called spadin.

What it does: researchers study how it relates to a specific brain-signaling channel called TREK-1. It lives on the Brain + Mood shelf near Semax.

What it actually does

PE-22-28 is a short peptide derived from spadin. Researchers study how it relates to a brain-cell channel called TREK-1, one of the gates that controls neural signaling.

It's a newer compound with an early research file. We're describing the mechanism studied, not promising an outcome.

The research so far

PE-22-28 is studied for its relationship to the TREK-1 channel. It's newer, so the data is limited. You can browse the literature on PubMed. (No clean single PubChem entry, so structural rows are left off rather than guessed.)

Featured angle

The TREK-1 channel angle

PE-22-28 is studied for how it relates to the TREK-1 brain channel in lab models. The research is early and the file is thin. None of it is a claim about what it does for a person.

Neuroscience research
TREK-1

The specific channel it's studied for.

Spadin-derived

Built from a natural molecule.

Research only

We stock it for research. The studies write the conclusions, not us.

A newer, targeted brain peptide with an honest early-stage file.

PE-22-28 specs

Compound specification SKU PP-PE-22-28-10MG
Also known as
PE-22-28
What it is
Synthetic peptide
Purity
≥99% HPLC
Format
Freeze-dried powder
Storage
Keep it cold and out of the light

The backstory

PE-22-28 was developed from spadin for channel research.

  1. Spadin roots

    Derived from a natural molecule.

  2. Channel focus

    Built to study the TREK-1 channel.

  3. Where it stands

    An early-stage research peptide. We're not telling you what it does for you, just the pathway studied.

Buying PE-22-28 in Canada

The short version

Read the COA before you buy, not after

Every batch ships with its Certificate of Analysis, right here on this page. A number on a label means nothing without the paper to back it.

Same-day, packed cold

Order PE-22-28 in Canada and it's out the door today. Cold chain, domestic shipping.

Freeze-dried vial

Lyophilized powder, sealed. No ice required for shipping.

Sold for research

Not for human consumption. Nothing on this page is a medical claim.

Pairs with the rest of the shelf

Semax

A brain-research peptide.

View compound →

Selank

A calm-signaling brain peptide.

View compound →

Order it

PE-22-28, lyophilized, COA on the page

For research use only. A spadin-derived research peptide with a clean Certificate of Analysis right here.

Add PE-22-28 to cart Read the COA first

Not for human consumption. Not approved by Health Canada or any other regulatory body. This product is intended for in vitro and laboratory research applications only.

Certificate of Analysis

HPLC verified. The COA ships with every batch.

99.4%
HPLC Purity
✓ COA Verified

Batch PP-PE2228-5MG-A

Tested
April 2026
Method
HPLC + Mass Spectrometry
Vial size
10mg lyophilized
Stored at
2 to 8°C, dark

Test results

HPLC verified
HPLC Purity99.4%✓ Pass
Mass spec confirmationConfirmed✓ Pass
Net peptide contentWithin spec✓ Pass
Endotoxin screenBelow detection✓ Pass
Visual inspectionUniform white powder✓ Pass
Every order ships with the COA matching that specific batch. If your source does not provide a COA, that is not a source. That is a mystery box.

Customer reviews

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Stuff people ask us

If your question's not here, email us. Real human answers.

What is PE-22-28?
PE-22-28 is a synthetic peptide derived from spadin, studied in neuroscience research for its relationship to the brain TREK-1 channel. Sold as a lyophilized powder for research use only.
What is PE-22-28 derived from?
PE-22-28 is derived from spadin and studied for how it relates to the TREK-1 potassium channel in early-stage lab research.
How is the purity verified?
Every batch is tested by HPLC to at least 99% purity, and the Certificate of Analysis for that batch ships with the order and is shown on the product page.
How should it be stored?
Store the lyophilized powder cold and protected from light. Keep it sealed until use to maintain stability.
Does it come with a COA?
Yes. Every batch ships with its Certificate of Analysis, shown right on the product page, so you can confirm purity before you buy.
What does "research use only" mean?
It means this product is intended strictly for laboratory research. It is not for human or animal consumption, and nothing on this page is a medical or therapeutic claim.

Not for human consumption. Not approved by Health Canada. For in vitro research only.

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