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MOTS-c Peptide

A peptide your mitochondria write themselves, a memo from the cell's power plant about burning energy. Studied in metabolic research.
Vial size 5mg Use Peptide Planner

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SKU: PP-MOTSC-5MG

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What MOTS-c is

Mitochondrial peptide, plain

Most peptides are coded by your main DNA. This one is coded by your mitochondria.

A genuinely weird origin story.

Here's the genuinely strange part: MOTS-c is encoded by your mitochondria, not your main DNA.

(A peptide is a short chain of the building blocks your body uses.) Your mitochondria are the little power plants inside your cells, and they turn out to carry instructions for a few tiny peptides of their own. MOTS-c is one, just 16 amino acids long.

It lives on the Skin + Longevity shelf next to other cellular-energy compounds like NAD+.

What it actually does

MOTS-c is studied for how it relates to cellular energy and metabolism, especially a sensor called AMPK that helps cells manage their energy budget.

The idea researchers poke at is that this little mitochondrial message helps coordinate how cells respond to metabolic stress. Mostly cell and animal work. That is the mechanism. We're describing what gets studied, not promising an outcome.

The research so far

MOTS-c was first described in 2015, which makes it young, and its mitochondrial origin makes it unusual. You can dig into the literature on PubMed.

AMPK pathway

The energy-sensing pathway research points at.

Mitochondrial origin

Coded by the power plant's own DNA.

Research only

We stock it for research. The studies write the conclusions, not us.

One of the few peptides your power plants wrote themselves.

MOTS-c specs

Compound specification SKU PP-MOTSC-5MG
Also known as
Mitochondrial ORF of the 12S rRNA type-c
What it is
Mitochondrial-derived peptide
Sequence
MRWQEMGYIFYPRKLR (16-aa)
Molecular formula
C101H152N28O22S2
Molecular weight
2174.6 g/mol
CAS number
1627580-64-6
Purity
≥99% HPLC
Format
Freeze-dried powder
Storage
Keep it cold and out of the light

The backstory

MOTS-c was found in a stretch of mitochondrial DNA nobody expected to make peptides.

  1. Found in 2015

    Identified within the 12S rRNA region of mitochondrial DNA.

  2. A new category

    Helped define mitochondrial-derived peptides as a research class.

  3. Where it stands

    Young, novel, and actively studied. We're not telling you what it does for you, just where the studies look.

Buying MOTS-c in Canada

The short version

Read the COA before you buy, not after

Every batch ships with its Certificate of Analysis, right here on this page. A number on a label means nothing without the paper to back it.

Same-day, packed cold

Order MOTS-c in Canada and it's out the door today. Cold chain, domestic shipping.

Freeze-dried 5mg vial

Lyophilized powder, sealed. No ice required for shipping.

Sold for research

Not for human consumption. Nothing on this page is a medical claim.

Pairs with the rest of the shelf

Order it

MOTS-c, lyophilized, COA on the page

For research use only. A mitochondrial-derived peptide with a clean Certificate of Analysis right here.

Not for human consumption. Not approved by Health Canada or any other regulatory body. This product is intended for in vitro and laboratory research applications only.

Certificate of Analysis

HPLC verified. The COA ships with every batch.

99.4%
HPLC Purity
✓ COA Verified

Batch PP-MOTSC-5MG-A

Tested
April 2026
Method
HPLC + Mass Spectrometry
Vial size
10mg lyophilized
Stored at
2 to 8°C, dark

Test results

HPLC verified
HPLC Purity99.4%✓ Pass
Mass spec confirmationConfirmed✓ Pass
Net peptide contentWithin spec✓ Pass
Endotoxin screenBelow detection✓ Pass
Visual inspectionUniform white powder✓ Pass
Every order ships with the COA matching that specific batch. If your source does not provide a COA, that is not a source. That is a mystery box.

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Stuff people ask us

If your question's not here, email us. Real human answers.

What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in metabolic research for the AMPK energy pathway. Sold as a lyophilized powder for research use only.
What is the molecular weight of MOTS-c?
MOTS-c has a molecular weight of 2174.6 g/mol and the molecular formula C101H152N28O22S2 (CAS 1627580-64-6).
How is the purity verified?
Every batch is tested by HPLC to at least 99% purity, and the Certificate of Analysis for that batch ships with the order and is shown on the product page.
How should it be stored?
Store the lyophilized powder cold and protected from light. Keep it sealed until use to maintain stability.
Does it come with a COA?
Yes. Every batch ships with its Certificate of Analysis, shown right on the product page, so you can confirm purity before you buy.
What does "research use only" mean?
It means this product is intended strictly for laboratory research. It is not for human or animal consumption, and nothing on this page is a medical or therapeutic claim.

Not for human consumption. Not approved by Health Canada. For in vitro research only.